Michael Oliver| 12 |  | Keylor Navas | |||
| 24 |  | Aurier | 64 | ||
| 19 |  | Niakhate | |||
| 38 |  | Felipe | |||
| 32 |  | Lodi | 81 | 78 | |
| 28 |  | Danilo | 73 | ||
| 22 |  | Yates | 70 | ||
| 10 |  | Gibbs-White | 44 | ||
| 5 |  | Mangala | |||
| 20 |  | Johnson | 81 | ||
| 9 |  | Awoniyi | 81 | 18 21 |
| 1 |  | McCarthy | |||
| 3 |  | Maitland-Niles | |||
| 2 |  | Walker-Peters | |||
| 37 |  | Bella-Kotchap | 38 | ||
| 35 |  | Bednarek | |||
| 45 |  | Lavia | |||
| 26 |  | Alcaraz | 76 | 25 | |
| 8 |  | Ward-Prowse | 90+6 | ||
| 17 |  | Armstrong | 76 | ||
| 10 |  | Adams | 76 | ||
| 32 |  | Walcott | 61 |
Substitutes
| 4 |  | Lyanco | 38 | 51 | |
| 23 |  | Edozie | 76 | ||
| 9 |  | Armstrong | 76 | ||
| 20 |  | Sulemana | 61 | ||
| 12 |  | Onuachu | 76 | ||
| 6 |  | Ćaleta-Car | |||
| 31 |  | Bazunu | |||
| 24 |  | Elyounoussi | |||
| 18 |  | Mara |
Managers
Milestones
Doublet #1 of Awoniyi in Premier League
Match #100 of Walker-Peters in Premier League with club Southampton
Goal #1 of Lyanco in Premier League