John Brooks| 1 |  | José Sá | |||
| 19 |  | Jonny Otto | 27 | ||
| 23 |  | Kilman | |||
| 4 |  | Collins | |||
| 3 |  | Aït Nouri | |||
| 27 |  | Matheus Nunes | |||
| 8 |  | Rúben Neves | 81 | ||
| 28 |  | Moutinho | 76 | ||
| 7 |  | Pedro Neto | 82 | ||
| 10 |  | Daniel Podence | 82 | 45+1 | |
| 18 |  | Kalajdžić | 46 |
| 31 |  | Bazunu | |||
| 2 |  | Walker-Peters | |||
| 37 |  | Bella-Kotchap | 90+5 | ||
| 22 |  | Salisu | |||
| 15 |  | Perraud | 73 | ||
| 27 |  | Diallo | 56 | 45 | |
| 7 |  | Aribo | 73 | ||
| 8 |  | Ward-Prowse | |||
| 10 |  | Adams | |||
| 9 |  | Armstrong | 83 | ||
| 24 |  | Elyounoussi | 56 |
Substitutes
Managers
Milestones
Match #1 of Kalajdžić in Premier League
Match #1 of Maitland-Niles in Premier League with club Southampton
Match #1 of Edozie in Premier League