Michael Salisbury| 1 |  | José Sá | |||
| 22 |  | Semedo | |||
| 24 |  | Toti | |||
| 23 |  | Kilman | |||
| 16 |  | Coady | 59 | ||
| 3 |  | Aït Nouri | |||
| 28 |  | Moutinho | |||
| 32 |  | Dendoncker | |||
| 11 |  | Trincão | 78 | ||
| 10 |  | Daniel Podence | 90+6 | 43 | |
| 9 |  | Raúl Jiménez | 80 | 62 37 |
| 44 |  | Forster | |||
| 22 |  | Salisu | 87 | ||
| 4 |  | Lyanco | 58 | ||
| 35 |  | Bednarek | |||
| 15 |  | Perraud | |||
| 27 |  | Diallo | 46 | ||
| 8 |  | Ward-Prowse | 86 84 | ||
| 6 |  | Romeu | |||
| 23 |  | Tella | 71 | ||
| 11 |  | Redmond | |||
| 18 |  | Broja | 78 |
Substitutes
| 39 |  | Cundle | 90+6 | ||
| 17 |  | Fábio Silva | 80 | ||
| 37 |  | Adama | 78 | 90+1 | |
| 34 |  | Sanderson | |||
| 21 |  | Ruddy | |||
| 77 |  | Campbell | |||
| 33 |  | Giles | |||
| 13 |  | Moulden | |||
| 6 |  | Bruno Jordão |
Managers
Milestones
Match #1 of Toti in Premier League
Match #1 of Cundle in Premier League
Match #100 of Armstrong in Premier League (all with club Southampton)