Mike Dean| 1 |  | José Sá | |||
| 22 |  | Semedo | |||
| 27 |  | Saïss | 84 | ||
| 23 |  | Kilman | |||
| 16 |  | Coady | 87 | ||
| 5 |  | Marçal | |||
| 8 |  | Rúben Neves | 81 | ||
| 28 |  | Moutinho | |||
| 11 |  | Trincão | 70 | ||
| 37 |  | Adama | 87 | ||
| 9 |  | Raúl Jiménez |
| 1 |  | De Gea | |||
| 29 |  | Wan-Bissaka | |||
| 5 |  | Maguire | |||
| 19 |  | Varane | |||
| 23 |  | Shaw | |||
| 21 |  | James | 53 | ||
| 18 |  | Bruno Fernandes | 44 | ||
| 17 |  | Fred | 84 | ||
| 6 |  | Pogba | 90+3 | ||
| 11 |  | Greenwood | 90 | 80 | |
| 25 |  | Sancho | 72 |
Substitutes
| 18 |  | Gibbs-White | 87 | 90+2 | |
| 17 |  | Fábio Silva | 87 | ||
| 10 |  | Daniel Podence | 70 | ||
| 32 |  | Dendoncker | |||
| 39 |  | Cundle | |||
| 2 |  | Hoever | |||
| 15 |  | Boly | |||
| 3 |  | Aït Nouri | |||
| 21 |  | Ruddy |
Managers
Milestones
Match #1 of Varane in Premier League
Match #50 of James in Premier League (all with club Manchester United)
Match #100 of Solskjær in Premier League with club Manchester United