Andre Marriner| 11 |  | Rui Patrício | |||
| 22 |  | Semedo | |||
| 49 |  | Kilman | |||
| 15 |  | Boly | |||
| 3 |  | Aït Nouri | |||
| 8 |  | Rúben Neves | 70 | 44 | |
| 32 |  | Dendoncker | |||
| 28 |  | Moutinho | |||
| 37 |  | Adama | 45+2 | ||
| 10 |  | Daniel Podence | 85 | ||
| 9 |  | Raúl Jiménez |
| 1 |  | McCarthy | |||
| 2 |  | Walker-Peters | |||
| 35 |  | Bednarek | |||
| 4 |  | Vestergaard | |||
| 3 |  | Bertrand | |||
| 8 |  | Ward-Prowse | |||
| 17 |  | Armstrong | 90 | ||
| 6 |  | Romeu | |||
| 10 |  | Adams | |||
| 32 |  | Walcott | 58 | ||
| 12 |  | Djénépo | 79 |
Substitutes
| 7 |  | Pedro Neto | 70 | 75 | |
| 20 |  | Vitinha | 85 | ||
| 21 |  | Ruddy | |||
| 17 |  | Fábio Silva | |||
| 2 |  | Hoever | |||
| 54 |  | Otasowie | |||
| 5 |  | Marçal |
Managers
Milestones
Match #50 of Vestergaard in Premier League (all with club Southampton)
Goal #1 of Walcott in Premier League with club Southampton