Maurizio Mariani| 16 |  | Maignan | 90+7 | ||
| 56 |  | Saelemaekers | 65 | ||
| 31 |  | Pavlović | 90+7 | ||
| 46 |  | Gabbia | 75 | 70 | |
| 23 |  | Tomori | 90+9 | ||
| 33 |  | Bartesaghi | |||
| 12 |  | Rabiot | |||
| 14 |  | Modrić | |||
| 19 |  | Fofana | 46 | ||
| 10 |  | Leão | 90+2 | ||
| 11 |  | Pulisic |
| 1 |  | Leali | 80 | ||
| 15 |  | Norton-Cuffy | |||
| 22 |  | Vásquez | |||
| 5 |  | Østigård | |||
| 27 |  | Marcandalli | |||
| 3 |  | Aarón | 83 | ||
| 2 |  | Thorsby | 63 | ||
| 17 |  | Malinovskyi | 64 | ||
| 32 |  | Frendrup | |||
| 29 |  | Colombo | 83 | 28 | |
| 9 |  | Vitinha | 75 |
Substitutes
| 24 |  | Athekame | 75 | ||
| 9 |  | Füllkrug | 65 | ||
| 8 |  | Loftus-Cheek | 46 | ||
| 1 |  | Terracciano | |||
| 96 |  | Torriani | |||
| 2 |  | Estupiñán | |||
| 4 |  | Ricci | |||
| 5 |  | De Winter | |||
| 27 |  | Odogu | |||
| 30 |  | Jashari | |||
| 38 |  | Castiello |
| 77 |  | Ellertsson | 64 | ||
| 73 |  | Masini | 63 | ||
| 8 |  | Stanciu | 83 | 90+9 | |
| 21 |  | Ekhator | 75 | ||
| 34 |  | Otoa | 83 | ||
| 35 |  | Lysionok | |||
| 39 |  | Sommariva | |||
| 20 |  | Sabelli | |||
| 30 |  | Cuenca | |||
| 40 |  | Fini | |||
| 76 |  | Venturino | |||
| 86 |  | Nuredini |
Managers
Milestones
Match #50 of Leali in Serie A with club Genoa
Match #100 of Frendrup in Serie A (all with club Genoa)