1
Hernández Hernández| 1 |  | Valles | |||
| 2 |  | Bellerín | |||
| 4 |  | Natan | 90+3 | ||
| 3 |  | Diego Llorente | 39 | ||
| 11 |  | Fran García | |||
| 8 |  | Fornals | |||
| 22 |  | Isco | 60 | ||
| 21 |  | Marc Roca | 83 | ||
| 6 |  | Bernal | 69 | 64 | |
| 9 |  | Cucho Hernández | 69 | ||
| 7 |  | Antony | 77 |
| 1 |  | Courtois | |||
| 24 |  | Dumfries | 64 | ||
| 4 |  | Huijsen | |||
| 16 |  | Konaté | 55 | ||
| 17 |  | Cucurella | 88 | ||
| 5 |  | Bellingham | |||
| 15 |  | Güler | 64 | 45+3 | |
| 6 |  | Camavinga | 64 | 62 | |
| 8 |  | Valverde | 82 | ||
| 10 |  | Mbappé | 90+4 | ||
| 7 |  | Vinícius | 90+9 |
Substitutes
| 5 |  | Bartra | 39 | ||
| 18 |  | Deossa | 69 | ||
| 17 |  | Riquelme | 77 | ||
| 15 |  | Fidalgo | 60 | ||
| 19 |  | Parrott | 69 | 81 | |
| 40 |  | De Pablo | |||
| 31 |  | Manu | |||
| 23 |  | Junior Firpo | |||
| 16 |  | Valentín Gómez | |||
| 12 |  | Ortiz | |||
| 14 |  | Losada | |||
| 27 |  | Morante |
| 12 |  | Alexander-Arnold | 64 | ||
| 18 |  | Álvaro Carreras | 88 | ||
| 19 |  | Espí | 82 | ||
| 20 |  | Bernardo Silva | 64 | ||
| 25 |  | Diomande | 64 | ||
| 13 |  | Lunin | |||
| 31 |  | Javi Navarro | |||
| 22 |  | Rüdiger | |||
| 33 |  | Rivas | |||
| 21 |  | Brahim Díaz | |||
| 29 |  | Cestero | |||
| 38 |  | Sergio |
Managers
 | Mourinho | 55 |
Milestones
Match #50 of Diego Llorente in First Division with club Betis
Goal #1 of Parrott in First Division