| Round 1 | |||||
| Date | Home | Away | Stadium | Referee | |
|---|---|---|---|---|---|
| 03/03/2018 | BMO Field | Ismail Elfath | |||
| 03/03/2018 | BBVA Stadium | Allen Chapman | |||
| 04/03/2018 | Talen Energy Stadium | Rubiel Vazquez | |||
| 04/03/2018 | Exploria Stadium | Fotis Bazakos | |||
| 04/03/2018 | Toyota Stadium | Robert Sibiga | |||
| 04/03/2018 | Earthquakes Stadium | Baldomero Toledo | |||
| 04/03/2018 | CenturyLink Field | José Carlos Rivero | |||
| 05/03/2018 | BC Place | Drew Fischer | |||
| 05/03/2018 | Children's Mercy Park | Mark Geiger | |||
| 05/03/2018 | Dignity Health Sports Park | Jair Marrufo | |||
| Round 2 | |||||
| Date | Home | Away | Stadium | Referee | |
| 10/03/2018 | Mapfre Stadium | Chris Penso | |||
| 10/03/2018 | Gillette Stadium | Armando Villarreal | |||
| 10/03/2018 | Rio Tinto Stadium | Baldomero Toledo | |||
| 11/03/2018 | SeatGeek Stadium | José Carlos Rivero | |||
| 11/03/2018 | BBVA Stadium | Ted Unkel | |||
| 11/03/2018 | Red Bull Arena | Allen Chapman | |||
| 11/03/2018 | Exploria Stadium | Sorin Stoica | |||
| 11/03/2018 | Mercedes-Benz Stadium | Robert Sibiga | |||
| 11/03/2018 | Yankee Stadium | Ismail Elfath | |||
| Round 3 | |||||
| Date | Home | Away | Stadium | Referee | |
| 17/03/2018 | Maryland SoccerPlex | David Gantar | |||
| 17/03/2018 | TCF Bank Stadium | Alex Chilowicz | |||
| 17/03/2018 | Talen Energy Stadium | Nima Saghafi | |||
| 17/03/2018 | Stade Olympique | Robert Sibiga | |||
| 17/03/2018 | Yankee Stadium | José Carlos Rivero | |||
| 18/03/2018 | Mercedes-Benz Stadium | Ismail Elfath | |||
| 18/03/2018 | Children's Mercy Park | Allen Chapman | |||
| 18/03/2018 | Rio Tinto Stadium | Ted Unkel | |||
| 18/03/2018 | Toyota Stadium | Chris Penso | |||
| Round 4 | |||||
| Date | Home | Away | Stadium | Referee | |
| 24/03/2018 | Gillette Stadium | Jair Marrufo | |||
| 24/03/2018 | Toyota Stadium | Mark Geiger | |||
| 24/03/2018 | Mapfre Stadium | Drew Fischer | |||
| 25/03/2018 | Red Bull Arena | Hilario Grajeda | |||
| 25/03/2018 | Dick's Sporting Goods Park | Sorin Stoica | |||
| 25/03/2018 | BC Place | Fotis Bazakos | |||
| Round 5 | |||||
| Date | Home | Away | Stadium | Referee | |
| 31/03/2018 | BMO Field | Allen Chapman | |||
| 31/03/2018 | Exploria Stadium | Jair Marrufo | |||
| 31/03/2018 | Mapfre Stadium | José Carlos Rivero | |||
| 31/03/2018 | Dignity Health Sports Park | Mark Geiger | |||
| 01/04/2018 | SeatGeek Stadium | Drew Fischer | |||
| 01/04/2018 | TCF Bank Stadium | Chris Penso | |||
| 01/04/2018 | Earthquakes Stadium | Armando Villarreal | |||
| 01/04/2018 | BBVA Stadium | Sorin Stoica | |||
| 01/04/2018 | Children's Mercy Park | Baldomero Toledo | |||
| 01/04/2018 | Dick's Sporting Goods Park | Robert Sibiga | |||
| 01/04/2018 | CenturyLink Field | Ismail Elfath | |||
| Round 6 | |||||
| Date | Home | Away | Stadium | Referee | |
| 07/04/2018 | Gillette Stadium | José Carlos Rivero | |||
| 07/04/2018 | Mercedes-Benz Stadium | Ted Unkel | |||
| 08/04/2018 | Talen Energy Stadium | David Gantar | |||
| 08/04/2018 | Toyota Stadium | Rubiel Vazquez | |||
| 08/04/2018 | SeatGeek Stadium | Jair Marrufo | |||
| 08/04/2018 | Rio Tinto Stadium | Marcos de Oliveira | |||
| 08/04/2018 | Exploria Stadium | Baldomero Toledo | |||
| 09/04/2018 | Dignity Health Sports Park | Robert Sibiga | |||
| Round 7 | |||||
| Date | Home | Away | Stadium | Referee | |
| 12/04/2018 | Yankee Stadium | Mark Geiger | |||
| 14/04/2018 | Talen Energy Stadium | Chris Penso | |||
| 14/04/2018 | BC Place | Robert Sibiga | |||
| 14/04/2018 | Red Bull Arena | Armando Villarreal | |||
| 14/04/2018 | Dick's Sporting Goods Park | Baldomero Toledo | |||
| 14/04/2018 | SeatGeek Stadium | Ted Unkel | |||
| 15/04/2018 | Navy-Marine Corps Memorial Stadium | Ismail Elfath | |||
| 15/04/2018 | Gillette Stadium | Hilario Grajeda | |||
| 15/04/2018 | Providence Park | José Carlos Rivero | |||
| 15/04/2018 | Earthquakes Stadium | Nima Saghafi | |||
| 15/04/2018 | Children's Mercy Park | Drew Fischer | |||
| 16/04/2018 | Mercedes-Benz Stadium | Allen Chapman | |||
| Round 8 | |||||
| Date | Home | Away | Stadium | Referee | |
| 21/04/2018 | Children's Mercy Park | Kevin Stott | |||
| 21/04/2018 | Stade Saputo | Allen Chapman | |||
| 21/04/2018 | BBVA Stadium | Drew Fischer | |||
| 21/04/2018 | Red Bull Arena | Robert Sibiga | |||
| 22/04/2018 | Mapfre Stadium | Chris Penso | |||
| 22/04/2018 | Exploria Stadium | Ismail Elfath | |||
| 22/04/2018 | Toyota Stadium | Alan Kelly | |||
| 22/04/2018 | Rio Tinto Stadium | Joseph Dickerson | |||
| 22/04/2018 | Dignity Health Sports Park | Baldomero Toledo | |||
| 22/04/2018 | CenturyLink Field | Armando Villarreal | |||
| 23/04/2018 | Providence Park | Ted Unkel | |||
| Round 9 | |||||
| Date | Home | Away | Stadium | Referee | |
| 28/04/2018 | BC Place | Sorin Stoica | |||
| 28/04/2018 | Mercedes-Benz Stadium | Hilario Grajeda | |||
| 28/04/2018 | BMO Field | Alan Kelly | |||
| 28/04/2018 | Talen Energy Stadium | Armando Villarreal | |||
| 29/04/2018 | Mapfre Stadium | Fotis Bazakos | |||
| 29/04/2018 | Gillette Stadium | David Gantar | |||
| 29/04/2018 | TCF Bank Stadium | Ted Unkel | |||
| 29/04/2018 | Dignity Health Sports Park | Allen Chapman | |||
| 29/04/2018 | Dick's Sporting Goods Park | José Carlos Rivero | |||
| 30/04/2018 | Yankee Stadium | Ismail Elfath | |||
| 30/04/2018 | Banc of California Stadium | Kevin Stott | |||
| Round 10 | |||||
| Date | Home | Away | Stadium | Referee | |
| 05/05/2018 | BMO Field | José Carlos Rivero | |||
| 05/05/2018 | Stade Saputo | Baldomero Toledo | |||
| 05/05/2018 | Red Bull Arena | Kevin Stott | |||
| 05/05/2018 | TCF Bank Stadium | Nima Saghafi | |||
| 05/05/2018 | Banc of California Stadium | Jair Marrufo | |||
| 05/05/2018 | CenturyLink Field | Hilario Grajeda | |||
| 06/05/2018 | SeatGeek Stadium | Drew Fischer | |||
| 06/05/2018 | BBVA Stadium | Alan Kelly | |||
| 06/05/2018 | Children's Mercy Park | Armando Villarreal | |||
| 06/05/2018 | Earthquakes Stadium | Chris Penso | |||
| 06/05/2018 | Exploria Stadium | Robert Sibiga | |||
| Round 11 | |||||
| Date | Home | Away | Stadium | Referee | |
| 10/05/2018 | Mercedes-Benz Stadium | Mark Geiger | |||
| 10/05/2018 | Mapfre Stadium | Ramy Touchan | |||
| 10/05/2018 | BMO Field | Ted Unkel | |||
| 10/05/2018 | SeatGeek Stadium | Sorin Stoica | |||
| 10/05/2018 | Banc of California Stadium | Silviu Petrescu | |||
| 12/05/2018 | BC Place | Hilario Grajeda | |||
| 12/05/2018 | TCF Bank Stadium | Victor Rivas | |||
| 12/05/2018 | Stade Saputo | Kevin Stott | |||
| 12/05/2018 | Toyota Stadium | José Carlos Rivero | |||
| 13/05/2018 | Mapfre Stadium | Allen Chapman | |||
| 13/05/2018 | Gillette Stadium | Mark Geiger | |||
| 13/05/2018 | Dick's Sporting Goods Park | Ismail Elfath | |||
| 13/05/2018 | Rio Tinto Stadium | Rubiel Vazquez | |||
| 13/05/2018 | Providence Park | Robert Sibiga | |||
| 14/05/2018 | Exploria Stadium | Alan Kelly | |||
| 14/05/2018 | Banc of California Stadium | Chris Penso | |||
| Round 12 | |||||
| Date | Home | Away | Stadium | Referee | |
| 17/05/2018 | BC Place | Armando Villarreal | |||
| 19/05/2018 | BMO Field | Allen Chapman | |||
| 19/05/2018 | Yankee Stadium | David Gantar | |||
| 19/05/2018 | Providence Park | Drew Fischer | |||
| 19/05/2018 | Toyota Stadium | Ted Unkel | |||
| 20/05/2018 | Gillette Stadium | Sorin Stoica | |||
| 20/05/2018 | Talen Energy Stadium | Hilario Grajeda | |||
| 20/05/2018 | Earthquakes Stadium | Baldomero Toledo | |||
| 20/05/2018 | TCF Bank Stadium | Jair Marrufo | |||
| 20/05/2018 | SeatGeek Stadium | Silviu Petrescu | |||
| 21/05/2018 | Mercedes-Benz Stadium | Chris Penso | |||
| 21/05/2018 | Stade Saputo | Ismail Elfath | |||
| Round 13 | |||||
| Date | Home | Away | Stadium | Referee | |
| 26/05/2018 | BMO Field | Chris Penso | |||
| 26/05/2018 | BBVA Stadium | Allen Chapman | |||
| 26/05/2018 | Dignity Health Sports Park | Kevin Stott | |||
| 26/05/2018 | CenturyLink Field | Baldomero Toledo | |||
| 26/05/2018 | BC Place | Joseph Dickerson | |||
| 27/05/2018 | Red Bull Arena | Ted Unkel | |||
| 27/05/2018 | Exploria Stadium | Nima Saghafi | |||
| 27/05/2018 | TCF Bank Stadium | Alan Kelly | |||
| 27/05/2018 | Dick's Sporting Goods Park | Sorin Stoica | |||
| 27/05/2018 | Banc of California Stadium | Ismail Elfath | |||
| 28/05/2018 | Children's Mercy Park | Robert Sibiga | |||
| Round 14 | |||||
| Date | Home | Away | Stadium | Referee | |
| 31/05/2018 | Gillette Stadium | Silviu Petrescu | |||
| 31/05/2018 | Subaru Park | Fotis Bazakos | |||
| 31/05/2018 | Rio Tinto Stadium | David Gantar | |||
| 31/05/2018 | Dignity Health Sports Park | Drew Fischer | |||
| 02/06/2018 | Dick's Sporting Goods Park | Baldomero Toledo | |||
| 02/06/2018 | Providence Park | Alan Kelly | |||
| 03/06/2018 | Mercedes-Benz Stadium | Sorin Stoica | |||
| 03/06/2018 | Stade Saputo | Robert Sibiga | |||
| 03/06/2018 | Gillette Stadium | José Carlos Rivero | |||
| 03/06/2018 | Yankee Stadium | Hilario Grajeda | |||
| 03/06/2018 | Mapfre Stadium | Nima Saghafi | |||
| 03/06/2018 | Toyota Stadium | Allen Chapman | |||
| 03/06/2018 | SeatGeek Stadium | Ismail Elfath | |||
| 03/06/2018 | Rio Tinto Stadium | Kevin Stott | |||
| 04/06/2018 | Children's Mercy Park | Drew Fischer | |||
| Round 15 | |||||
| Date | Home | Away | Stadium | Referee | |
| 09/06/2018 | Subaru Park | Baldomero Toledo | |||
| 09/06/2018 | Yankee Stadium | Robert Sibiga | |||
| 09/06/2018 | Mapfre Stadium | Alan Kelly | |||
| 10/06/2018 | BC Place | José Carlos Rivero | |||
| 10/06/2018 | Toyota Stadium | Nima Saghafi | |||
| 10/06/2018 | SeatGeek Stadium | Kevin Stott | |||
| 10/06/2018 | BBVA Stadium | Drew Fischer | |||
| 10/06/2018 | CenturyLink Field | Sorin Stoica | |||
| 10/06/2018 | Dignity Health Sports Park | Ted Unkel | |||
| 10/06/2018 | Providence Park | Chris Penso | |||
| 10/06/2018 | Earthquakes Stadium | Hilario Grajeda | |||
| Round 16 | |||||
| Date | Home | Away | Stadium | Referee | |
| 14/06/2018 | Stade Saputo | Armando Villarreal | |||
| 14/06/2018 | Mapfre Stadium | Ted Unkel | |||
| 14/06/2018 | BMO Field | Robert Sibiga | |||
| 14/06/2018 | Red Bull Arena | Allen Chapman | |||
| 14/06/2018 | Dick's Sporting Goods Park | José Carlos Rivero | |||
| 14/06/2018 | Earthquakes Stadium | David Gantar | |||
| Round 17 | |||||
| Date | Home | Away | Stadium | Referee | |
| 23/06/2018 | Subaru Park | Allen Chapman | |||
| 24/06/2018 | Red Bull Arena | Robert Sibiga | |||
| 24/06/2018 | Exploria Stadium | Drew Fischer | |||
| 24/06/2018 | Children's Mercy Park | Alan Kelly | |||
| 24/06/2018 | Dick's Sporting Goods Park | Hilario Grajeda | |||
| 24/06/2018 | Rio Tinto Stadium | Silviu Petrescu | |||
| 24/06/2018 | CenturyLink Field | Armando Villarreal | |||
| 24/06/2018 | Banc of California Stadium | Kevin Stott | |||
| 24/06/2018 | Mercedes-Benz Stadium | José Carlos Rivero | |||
| 24/06/2018 | Yankee Stadium | Ismail Elfath | |||
| Round 18 | |||||
| Date | Home | Away | Stadium | Referee | |
| 30/06/2018 | TCF Bank Stadium | Baldomero Toledo | |||
| 30/06/2018 | CenturyLink Field | Ismail Elfath | |||
| 01/07/2018 | Mercedes-Benz Stadium | Kevin Stott | |||
| 01/07/2018 | Stade Saputo | Ted Unkel | |||
| 01/07/2018 | Mapfre Stadium | Drew Fischer | |||
| 01/07/2018 | Gillette Stadium | Allen Chapman | |||
| 01/07/2018 | SeatGeek Stadium | Chris Penso | |||
| 01/07/2018 | Banc of California Stadium | Robert Sibiga | |||
| 01/07/2018 | Stanford Stadium | José Carlos Rivero | |||
| 01/07/2018 | BMO Field | Hilario Grajeda | |||
| 02/07/2018 | BC Place | Nima Saghafi | |||
| Round 19 | |||||
| Date | Home | Away | Stadium | Referee | |
| 04/07/2018 | BBVA Stadium | Armando Villarreal | |||
| 05/07/2018 | TCF Bank Stadium | Rubiel Vazquez | |||
| 05/07/2018 | Toyota Stadium | Alan Kelly | |||
| 05/07/2018 | Dick's Sporting Goods Park | Fotis Bazakos | |||
| 05/07/2018 | Rio Tinto Stadium | Sorin Stoica | |||
| 05/07/2018 | Dignity Health Sports Park | Silviu Petrescu | |||
| 08/07/2018 | Subaru Park | Ismail Elfath | |||
| 08/07/2018 | Stade Saputo | Allen Chapman | |||
| 08/07/2018 | Gillette Stadium | Nima Saghafi | |||
| 08/07/2018 | Children's Mercy Park | José Carlos Rivero | |||
| 08/07/2018 | BBVA Stadium | Kevin Stott | |||
| 08/07/2018 | Rio Tinto Stadium | Armando Villarreal | |||
| 08/07/2018 | Dignity Health Sports Park | Hilario Grajeda | |||
| 08/07/2018 | BC Place | Robert Sibiga | |||
| 08/07/2018 | Providence Park | Ted Unkel | |||
| 08/07/2018 | Banc of California Stadium | Chris Penso | |||
| 09/07/2018 | Yankee Stadium | Baldomero Toledo | |||
| Round 20 | |||||
| Date | Home | Away | Stadium | Referee | |
| 12/07/2018 | Yankee Stadium | Alan Kelly | |||
| 12/07/2018 | SeatGeek Stadium | David Gantar | |||
| 15/07/2018 | Yankee Stadium | Armando Villarreal | |||
| 15/07/2018 | Red Bull Arena | Kevin Stott | |||
| 15/07/2018 | Stade Saputo | Joseph Dickerson | |||
| 15/07/2018 | Gillette Stadium | Robert Sibiga | |||
| 15/07/2018 | Audi Field | Hilario Grajeda | |||
| 15/07/2018 | Toyota Stadium | Marcos de Oliveira | |||
| 15/07/2018 | TCF Bank Stadium | Alan Kelly | |||
| 15/07/2018 | Exploria Stadium | Allen Chapman | |||
| 15/07/2018 | Dick's Sporting Goods Park | Ted Unkel | |||
| 15/07/2018 | Mercedes-Benz Stadium | Baldomero Toledo | |||
| 16/07/2018 | Banc of California Stadium | Silviu Petrescu | |||
| Round 21 | |||||
| Date | Home | Away | Stadium | Referee | |
| 19/07/2018 | TCF Bank Stadium | José Carlos Rivero | |||
| 21/07/2018 | Mercedes-Benz Stadium | Drew Fischer | |||
| 21/07/2018 | CenturyLink Field | Chris Penso | |||
| 22/07/2018 | Red Bull Arena | Ismail Elfath | |||
| 22/07/2018 | Subaru Park | Nima Saghafi | |||
| 22/07/2018 | SeatGeek Stadium | Sorin Stoica | |||
| 22/07/2018 | Mapfre Stadium | Silviu Petrescu | |||
| 22/07/2018 | BBVA Stadium | Hilario Grajeda | |||
| 22/07/2018 | Rio Tinto Stadium | Baldomero Toledo | |||
| 22/07/2018 | Providence Park | Fotis Bazakos | |||
| 23/07/2018 | TCF Bank Stadium | Ted Unkel | |||
| Round 22 | |||||
| Date | Home | Away | Stadium | Referee | |
| 26/07/2018 | BBVA Stadium | Joseph Dickerson | |||
| 26/07/2018 | Audi Field | Armando Villarreal | |||
| 26/07/2018 | Earthquakes Stadium | Kevin Stott | |||
| 27/07/2018 | Exploria Stadium | Robert Sibiga | |||
| 27/07/2018 | Banc of California Stadium | Alan Kelly | |||
| 29/07/2018 | Stade Saputo | Hilario Grajeda | |||
| 29/07/2018 | Red Bull Arena | Sorin Stoica | |||
| 29/07/2018 | BMO Field | Joseph Dickerson | |||
| 29/07/2018 | Audi Field | Ramy Touchan | |||
| 29/07/2018 | Children's Mercy Park | Drew Fischer | |||
| 29/07/2018 | BC Place | David Gantar | |||
| 29/07/2018 | Earthquakes Stadium | Marcos de Oliveira | |||
| 29/07/2018 | Providence Park | Nima Saghafi | |||
| 29/07/2018 | CenturyLink Field | Jair Marrufo | |||
| 30/07/2018 | Dignity Health Sports Park | Armando Villarreal | |||
| Round 23 | |||||
| Date | Home | Away | Stadium | Referee | |
| 04/08/2018 | Mercedes-Benz Stadium | Armando Villarreal | |||
| 05/08/2018 | Stade Saputo | Ismail Elfath | |||
| 05/08/2018 | Exploria Stadium | Hilario Grajeda | |||
| 05/08/2018 | Toyota Stadium | David Gantar | |||
| 05/08/2018 | TCF Bank Stadium | Drew Fischer | |||
| 05/08/2018 | Yankee Stadium | José Carlos Rivero | |||
| 05/08/2018 | Dick's Sporting Goods Park | Sorin Stoica | |||
| 05/08/2018 | BBVA Stadium | Chris Penso | |||
| 05/08/2018 | Rio Tinto Stadium | Kevin Stott | |||
| 05/08/2018 | Providence Park | Alan Kelly | |||
| 06/08/2018 | Red Bull Arena | Allen Chapman | |||
| Round 24 | |||||
| Date | Home | Away | Stadium | Referee | |
| 12/08/2018 | Mapfre Stadium | Mark Geiger | |||
| 12/08/2018 | Gillette Stadium | Allen Chapman | |||
| 12/08/2018 | SeatGeek Stadium | Nima Saghafi | |||
| 12/08/2018 | Dick's Sporting Goods Park | Alan Kelly | |||
| 12/08/2018 | Rio Tinto Stadium | Chris Penso | |||
| 12/08/2018 | Dignity Health Sports Park | Baldomero Toledo | |||
| 12/08/2018 | Banc of California Stadium | Ismail Elfath | |||
| 12/08/2018 | Providence Park | Jair Marrufo | |||
| 12/08/2018 | BMO Field | Hilario Grajeda | |||
| 13/08/2018 | Audi Field | José Carlos Rivero | |||
| 13/08/2018 | CenturyLink Field | Ted Unkel | |||
| Round 25 | |||||
| Date | Home | Away | Stadium | Referee | |
| 15/08/2018 | Dignity Health Sports Park | Kevin Stott | |||
| 16/08/2018 | Audi Field | Robert Sibiga | |||
| 16/08/2018 | Banc of California Stadium | David Gantar | |||
| 18/08/2018 | CenturyLink Field | Mark Geiger | |||
| 19/08/2018 | Subaru Park | Fotis Bazakos | |||
| 19/08/2018 | BC Place | Joseph Dickerson | |||
| 19/08/2018 | Stade Saputo | Baldomero Toledo | |||
| 19/08/2018 | Children's Mercy Park | Allen Chapman | |||
| 19/08/2018 | BBVA Stadium | Armando Villarreal | |||
| 19/08/2018 | Earthquakes Stadium | Silviu Petrescu | |||
| 19/08/2018 | Toyota Stadium | Ismail Elfath | |||
| 19/08/2018 | Mercedes-Benz Stadium | Jair Marrufo | |||
| 20/08/2018 | Audi Field | Ted Unkel | |||
| 20/08/2018 | Banc of California Stadium | Nima Saghafi | |||
| Round 26 | |||||
| Date | Home | Away | Stadium | Referee | |
| 23/08/2018 | Yankee Stadium | Ted Unkel | |||
| 24/08/2018 | SeatGeek Stadium | Armando Villarreal | |||
| 24/08/2018 | BBVA Stadium | Allen Chapman | |||
| 25/08/2018 | Exploria Stadium | Ismail Elfath | |||
| 25/08/2018 | Dignity Health Sports Park | Jair Marrufo | |||
| 26/08/2018 | Subaru Park | Drew Fischer | |||
| 26/08/2018 | BMO Field | Mark Geiger | |||
| 26/08/2018 | Children's Mercy Park | Robert Sibiga | |||
| 26/08/2018 | Dick's Sporting Goods Park | Ted Unkel | |||
| 26/08/2018 | Earthquakes Stadium | Baldomero Toledo | |||
| 27/08/2018 | Red Bull Arena | David Gantar | |||
| 27/08/2018 | Providence Park | Chris Penso | |||
| Round 27 | |||||
| Date | Home | Away | Stadium | Referee | |
| 30/08/2018 | Red Bull Arena | Robert Sibiga | |||
| 30/08/2018 | Audi Field | Nima Saghafi | |||
| 30/08/2018 | Earthquakes Stadium | Sorin Stoica | |||
| 30/08/2018 | Providence Park | Fotis Bazakos | |||
| 01/09/2018 | CenturyLink Field | Baldomero Toledo | |||
| 02/09/2018 | Stade Saputo | Jair Marrufo | |||
| 02/09/2018 | Gillette Stadium | José Carlos Rivero | |||
| 02/09/2018 | Exploria Stadium | Chris Penso | |||
| 02/09/2018 | Mapfre Stadium | Alan Kelly | |||
| 02/09/2018 | Toyota Stadium | Kevin Stott | |||
| 02/09/2018 | BMO Field | Ted Unkel | |||
| 02/09/2018 | Rio Tinto Stadium | Drew Fischer | |||
| 02/09/2018 | BC Place | Mark Geiger | |||
| 03/09/2018 | Audi Field | Allen Chapman | |||
| Round 28 | |||||
| Date | Home | Away | Stadium | Referee | |
| 06/09/2018 | Yankee Stadium | Armando Villarreal | |||
| 08/09/2018 | Yankee Stadium | Kevin Stott | |||
| 09/09/2018 | Children's Mercy Park | Alan Kelly | |||
| 09/09/2018 | Providence Park | Drew Fischer | |||
| Round 29 | |||||
| Date | Home | Away | Stadium | Referee | |
| 13/09/2018 | Audi Field | Silviu Petrescu | |||
| 15/09/2018 | Dick's Sporting Goods Park | Sorin Stoica | |||
| 16/09/2018 | Subaru Park | Armando Villarreal | |||
| 16/09/2018 | BMO Field | Nima Saghafi | |||
| 16/09/2018 | Toyota Stadium | Hilario Grajeda | |||
| 16/09/2018 | BBVA Stadium | Jair Marrufo | |||
| 16/09/2018 | Rio Tinto Stadium | Chris Penso | |||
| 16/09/2018 | BC Place | Robert Sibiga | |||
| 16/09/2018 | Banc of California Stadium | Mark Geiger | |||
| 16/09/2018 | Earthquakes Stadium | David Gantar | |||
| 16/09/2018 | Audi Field | Alan Kelly | |||
| 16/09/2018 | SeatGeek Stadium | Allen Chapman | |||
| Round 30 | |||||
| Date | Home | Away | Stadium | Referee | |
| 20/09/2018 | Providence Park | Ted Unkel | |||
| 20/09/2018 | CenturyLink Field | Ismail Elfath | |||
| 20/09/2018 | Earthquakes Stadium | Fotis Bazakos | |||
| 22/09/2018 | Banc of California Stadium | Robert Sibiga | |||
| 22/09/2018 | Red Bull Arena | Kevin Stott | |||
| 23/09/2018 | Mercedes-Benz Stadium | Hilario Grajeda | |||
| 23/09/2018 | Mapfre Stadium | Allen Chapman | |||
| 23/09/2018 | Stade Saputo | Nima Saghafi | |||
| 23/09/2018 | Gillette Stadium | Joseph Dickerson | |||
| 23/09/2018 | Exploria Stadium | Baldomero Toledo | |||
| 23/09/2018 | TCF Bank Stadium | David Gantar | |||
| 23/09/2018 | Subaru Park | Mark Geiger | |||
| 24/09/2018 | BC Place | Alan Kelly | |||
| 24/09/2018 | Dignity Health Sports Park | José Carlos Rivero | |||
| Round 31 | |||||
| Date | Home | Away | Stadium | Referee | |
| 27/09/2018 | Yankee Stadium | Jair Marrufo | |||
| 29/09/2018 | SeatGeek Stadium | Chris Penso | |||
| 29/09/2018 | CenturyLink Field | Nima Saghafi | |||
| 30/09/2018 | Audi Field | Ted Unkel | |||
| 30/09/2018 | Mapfre Stadium | Drew Fischer | |||
| 30/09/2018 | BMO Field | Ismail Elfath | |||
| 30/09/2018 | TCF Bank Stadium | José Carlos Rivero | |||
| 30/09/2018 | BBVA Stadium | Hilario Grajeda | |||
| 30/09/2018 | Dignity Health Sports Park | Baldomero Toledo | |||
| 30/09/2018 | Providence Park | Allen Chapman | |||
| 30/09/2018 | Red Bull Arena | Robert Sibiga | |||
| 30/09/2018 | Children's Mercy Park | Kevin Stott | |||
| Round 32 | |||||
| Date | Home | Away | Stadium | Referee | |
| 06/10/2018 | Stade Saputo | Alan Kelly | |||
| 06/10/2018 | Mercedes-Benz Stadium | Kevin Stott | |||
| 06/10/2018 | BMO Field | José Carlos Rivero | |||
| 07/10/2018 | Subaru Park | Allen Chapman | |||
| 07/10/2018 | Toyota Stadium | Nima Saghafi | |||
| 07/10/2018 | Children's Mercy Park | Jair Marrufo | |||
| 07/10/2018 | Dick's Sporting Goods Park | Armando Villarreal | |||
| 07/10/2018 | Rio Tinto Stadium | Robert Sibiga | |||
| 07/10/2018 | Earthquakes Stadium | Baldomero Toledo | |||
| 07/10/2018 | Audi Field | Ismail Elfath | |||
| 09/10/2018 | CenturyLink Field | Drew Fischer | |||
| Round 33 | |||||
| Date | Home | Away | Stadium | Referee | |
| 13/10/2018 | Banc of California Stadium | Alan Kelly | |||
| 13/10/2018 | TCF Bank Stadium | Guido Gonzales | |||
| 13/10/2018 | Audi Field | José Carlos Rivero | |||
| 14/10/2018 | Gillette Stadium | David Gantar | |||
| Round 34 | |||||
| Date | Home | Away | Stadium | Referee | |
| 18/10/2018 | Exploria Stadium | Mark Geiger | |||
| 18/10/2018 | Audi Field | Allen Chapman | |||
| 18/10/2018 | BC Place | Armando Villarreal | |||
| 19/10/2018 | Rio Tinto Stadium | Jair Marrufo | |||
| 21/10/2018 | Mercedes-Benz Stadium | Drew Fischer | |||
| 21/10/2018 | Audi Field | Hilario Grajeda | |||
| 21/10/2018 | Stade Saputo | Baldomero Toledo | |||
| 21/10/2018 | Exploria Stadium | Kevin Stott | |||
| 21/10/2018 | Subaru Park | Ted Unkel | |||
| 21/10/2018 | Toyota Stadium | Robert Sibiga | |||
| 21/10/2018 | BBVA Stadium | David Gantar | |||
| 21/10/2018 | Banc of California Stadium | Nima Saghafi | |||
| 21/10/2018 | TCF Bank Stadium | Alan Kelly | |||
| 21/10/2018 | Providence Park | Ismail Elfath | |||
| 21/10/2018 | Earthquakes Stadium | Timothy Ford | |||
| Round 35 | |||||
| Date | Home | Away | Stadium | Referee | |
| 28/10/2018 | SeatGeek Stadium | Nima Saghafi | |||
| 28/10/2018 | Dick's Sporting Goods Park | Chris Penso | |||
| 28/10/2018 | Mapfre Stadium | Robert Sibiga | |||
| 28/10/2018 | Dignity Health Sports Park | Kevin Stott | |||
| 28/10/2018 | Gillette Stadium | Armando Villarreal | |||
| 28/10/2018 | Yankee Stadium | Alan Kelly | |||
| 28/10/2018 | Red Bull Arena | Ismail Elfath | |||
| 28/10/2018 | CenturyLink Field | Hilario Grajeda | |||
| 28/10/2018 | Children's Mercy Park | Allen Chapman | |||
| 28/10/2018 | BMO Field | Jair Marrufo | |||
| 28/10/2018 | BC Place | Ted Unkel | |||
Clubs
23
Matches
391
Home wins
211
Away wins
97
Draws
83
Goals
1247
Goals scored
3,19
Goals Per Match
Yellow Cards
1350
Yellow Cards
3,45
Bookings Per Match
Red Cards
89
Red Cards
0,23
Sent Offs Per Match
Penalties
136
Penalties Scored
107
Penalties Missed
29
| Widest home win: 6 - 0 Sporting Kansas City-Vancouver Whitecaps |
| Widest away win: 0 - 6 Colorado Rapids-Real Salt Lake |
| Longest winning run: Seattle Sounders: 9 Matches |
| Longest losing run: Orlando City: 9 Matches |
| Longest no losing run: Portland Timbers: 15 Matches |
| Longest no winning run: Orlando City: 13 Matches |
| Match with most goals: 3 - 5 Montreal Impact-Los Angeles |